Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

Induced pluripotent stem (iPS) cells are derived by epigenetic reprogramming, but their DNA methylation patterns have not yet been analyzed on a genome-wide scale. Here, we find substantial hypermethylation and hypomethylation of cytosine-phosphate-guanine (CpG) island shores in nine human iPS cell...

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Detalhes bibliográficos
Main Authors: Doi, Akiko, Park, In-Hyun, Wen, Bo, Murakami, Peter, Aryee, Martin J, Irizarry, Rafael, Herb, Brian, Ladd-Acosta, Christine, Rho, Junsung, Loewer, Sabine, Miller, Justine, Schlaeger, Thorsten, Daley, George Q, Feinberg, Andrew P
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958040/
https://ncbi.nlm.nih.gov/pubmed/19881528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.471
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