Genome-wide methylation analysis of human colon cancer reveals similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

Alterations in DNA methylation (DNAm) in cancer have been known for 25 years, including hypomethylation of oncogenes and hypermethylation of tumor suppressor genes1. However, most studies of cancer methylation have assumed that functionally important DNAm will occur in promoters, and that most DNAm...

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Autors principals: Irizarry, Rafael A., Ladd-Acosta, Christine, Wen, Bo, Wu, Zhijin, Montano, Carolina, Onyango, Patrick, Cui, Hengmi, Gabo, Kevin, Rongione, Michael, Webster, Maree, Ji, Hong, Potash, James, Sabunciyan, Sarven, Feinberg, Andrew P.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729128/
https://ncbi.nlm.nih.gov/pubmed/19151715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.298
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