5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.

5-Lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) are two key proteins involved in the synthesis of leukotrienes (LT) from arachidonic acid. Although both alveolar macrophages (AM) and peripheral blood leukocytes (PBL) produce large amounts of LT after activation, 5-LO translocates...

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Bibliographic Details

Published in:	J Clin Invest
Main Authors:	Woods, J W, Coffey, M J, Brock, T G, Singer, I I, Peters-Golden, M
Format:	Artigo
Language:	Inglês
Published:	American Society for Clinical Investigation 1995
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295787/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7738170/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117889
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