5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.

5-Lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) are two key proteins involved in the synthesis of leukotrienes (LT) from arachidonic acid. Although both alveolar macrophages (AM) and peripheral blood leukocytes (PBL) produce large amounts of LT after activation, 5-LO translocates...

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Pubblicato in:	J Clin Invest
Autori principali:	Woods, J W, Coffey, M J, Brock, T G, Singer, I I, Peters-Golden, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295787/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7738170/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117889
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