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Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival.

To study the in vivo role of alveolar macrophages (AM) in gram-negative bacterial pneumonia in mice, AM were eliminated by the intratracheal (i.t.) administration of dichloromethylene diphosphonate encapsulated liposomes. Subsequently, the AM-depleted mice were infected i.t. with 100 CFU of Klebsiel...

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Bibliografski detalji
Glavni autori: Broug-Holub, E, Toews, G B, van Iwaarden, J F, Strieter, R M, Kunkel, S L, Paine, R, Standiford, T J
Format: Artigo
Jezik:Inglês
Izdano: 1997
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC175109/
https://ncbi.nlm.nih.gov/pubmed/9119443
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