Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival.

To study the in vivo role of alveolar macrophages (AM) in gram-negative bacterial pneumonia in mice, AM were eliminated by the intratracheal (i.t.) administration of dichloromethylene diphosphonate encapsulated liposomes. Subsequently, the AM-depleted mice were infected i.t. with 100 CFU of Klebsiel...

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Publicado en:	Infect Immun
Autores principales:	Broug-Holub, E, Toews, G B, van Iwaarden, J F, Strieter, R M, Kunkel, S L, Paine, R, Standiford, T J
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175109/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9119443/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.65.4.1139-1146.1997
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