Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe

Reversible protein phosphorylation is a major regulatory mechanism in a cell. A chemical-genetic strategy to conditionally inactivate protein kinases has been developed recently. Mutating a single residue in the ATP-binding pocket confers sensitivity to small-molecule inhibitors. The inhibitor can o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gregan, Juraj, Zhang, Chao, Rumpf, Cornelia, Cipak, Lubos, Li, Zhang, Uluocak, Pelin, Nasmyth, Kim, Shokat, Kevan M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957860/
https://ncbi.nlm.nih.gov/pubmed/18007635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2007.447
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg