Rescue of Cytotoxic Function in the CD8α Knockout Mouse by Removal of MHC II

CD8 plays an important role in the activity of cytolytic T cells (CTL). However, whether or not CD8 is required for the development of CTL has not been clearly determined. Cytotoxic activity in the CD8α knockout mouse is difficult to induce, and has only been demonstrated against allogenic MHC targe...

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Detalhes bibliográficos
Principais autores: Riddle, David S., Miller, Peter J., Vincent, Benjamin G., Kepler, Thomas B., Maile, Rob, Frelinger, Jeffrey A., Collins, Edward J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957804/
https://ncbi.nlm.nih.gov/pubmed/18465769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200737710
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