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Toxin coupled MHC class I tetramers can specifically ablate autoreactive CD8(+) T cells and delay diabetes in NOD mice
There is compelling evidence that self reactive CD8(+) T cells are a major factor in development and progression of Type 1 diabetes in animals and humans. Hence, great effort has been expended to define the specificity of autoimmune CD8(+) T cells, and to alter their responses. Much work has focused...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2868268/ https://ncbi.nlm.nih.gov/pubmed/20220085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903931 |
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