Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance

Alloreactive T-cell responses directed against minor histocompatibility (H) antigens, which arise from diverse genetic disparities between donor and recipient outside the MHC, are an important cause of rejection of MHC-matched grafts. Because clinically significant responses appear to be directed at...

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Huvudupphovsmän: Hess, Sabrina M., Young, Ellen F., Miller, Keith R., Vincent, Benjamin G., Buntzman, Adam S., Collins, Edward J., Frelinger, Jeffrey A., Hess, Paul R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867971/
https://ncbi.nlm.nih.gov/pubmed/24161680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trim.2013.10.005
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