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Cytotoxic effector function of CD4-independent, CD8(+) T cells is mediated by TNF-α/TNFR

BACKGROUND: Liver parenchymal cell allografts initiate both CD4-dependent and CD4-independent, CD8(+) T cell-mediated acute rejection pathways. The magnitude of allospecific CD8(+) T cell in vivo cytotoxic effector function is maximal when primed in the presence of CD4(+) T cells. The current studie...

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Main Authors: Zimmerer, Jason M., Horne, Phillip H., Fiessinger, Lori A., Fisher, Mason G., Pham, Thomas A., Saklayen, Samiya L., Bumgardner, Ginny L.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522862/
https://ncbi.nlm.nih.gov/pubmed/23222736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e318270f3c0
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