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Alloreactive (CD4-independent) CD8(+) T cells jeopardize long-term survival of intrahepatic islet allografts

Despite success of early islet allograft engraftment and survival in humans, late islet allograft loss has emerged as an important clinical problem. CD8(+) T cells that are independent of CD4(+) T cell help can damage allograft tissues and are resistant to conventional immunosuppressive therapies. P...

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Detalhes bibliográficos
Main Authors: Lunsford, Keri E., Jayanshankar, Kartika, Eiring, Anna M., Horne, Phillip H., Koester, Mitchel A., Gao, Donghong, Bumgardner, Ginny L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081659/
https://ncbi.nlm.nih.gov/pubmed/18522544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2008.02219.x
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