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Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCδ proteolytic activation and mitochondrial translocation

Emerging evidence implicates impaired protein degradation by the ubiquitin proteasome system (UPS) in Parkinson's disease; however cellular mechanisms underlying dopaminergic degeneration during proteasomal dysfunction are yet to be characterized. In the present study, we identified that the no...

詳細記述

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書誌詳細
主要な著者: Sun, Faneng, Kanthasamy, Arthi, Song, Chunjuan, Yang, Yongjie, Anantharam, Vellareddy, Kanthasamy, Anumantha G
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley & Sons, Ltd 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957660/
https://ncbi.nlm.nih.gov/pubmed/18298651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00293.x
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