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A Hierarchical Phosphorylation Cascade That Regulates the Timing of PERIOD Nuclear Entry Reveals Novel Roles for Proline-Directed Kinases and GSK-3β/SGG in Circadian Clocks

The daily timing of when PERIOD (PER) proteins translocate from the cytoplasm to the nucleus is a critical step in clock mechanisms underpinning circadian rhythms in animals. Numerous lines of evidence indicate that phosphorylation plays a prominent role in regulating various aspects of PER function...

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Main Authors: Ko, Hyuk Wan, Kim, Eun Young, Chiu, Joanna, Vanselow, Jens T., Kramer, Achim, Edery, Isaac
פורמט: Artigo
שפה:Inglês
יצא לאור: Society for Neuroscience 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957474/
https://ncbi.nlm.nih.gov/pubmed/20861372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1586-10.2010
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