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NEMO/NLK phosphorylates PERIOD to initiate a time-delay phosphorylation circuit that sets circadian clock speed
The speed of circadian clocks in animals is tightly linked to complex phosphorylation programs that drive daily cycles in the levels of PERIOD (PER) proteins. Using Drosophila we identify a time-delay circuit based on hierarchical phosphorylation that controls the daily downswing in PER abundance. P...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3092788/ https://ncbi.nlm.nih.gov/pubmed/21514639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.04.002 |
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