20-HETE increases NADPH oxidase-derived ROS production and stimulates the L-type Ca(2+) channel via a PKC-dependent mechanism in cardiomyocytes

The production of 20-hydroxyeicosatetraenoic acid (20-HETE) is increased during ischemia-reperfusion, and inhibition of 20-HETE production has been shown to reduce infarct size caused by ischemia. This study was aimed to discover the molecular mechanism underlying the action of 20-HETE in cardiac my...

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Detalhes bibliográficos
Main Authors: Zeng, Qinghua, Han, Yong, Bao, Yuyan, Li, Wei, Li, Xingting, Shen, Xin, Wang, Xu, Yao, Fanrong, O'Rourke, Stephen T., Sun, Chengwen
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957347/
https://ncbi.nlm.nih.gov/pubmed/20675568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00067.2010
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