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Hypoxia activates NADPH oxidase to increase [ROS](i) and [Ca(2+)](i) through mitochondrial ROS–PKCε signaling axis in pulmonary artery smooth muscle cells

The importance of NADPH oxidase (Nox) in hypoxic responses in hypoxia-sensing cells including pulmonary artery smooth muscle cells (PASMCs) remains uncertain. In this study, using Western blot analysis we found that the major Nox subunits Nox1, Nox4, p22(phox), p47(phox), and p67(phox) were equivale...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Rathore, Rakesh, Zheng, Yun-Min, Niu, Chun-Feng, Liu, Qing-Hua, Korde, Amit, Ho, Ye-Shih, Wang, Yong-Xiao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586914/
https://ncbi.nlm.nih.gov/pubmed/18638544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.06.012
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