An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila

In Drosophila, PIWI proteins and bound PIWI-interacting RNAs (piRNAs) form the core of a small RNA-mediated defense system against selfish genetic elements. Within germline cells, piRNAs are processed from piRNA clusters and transposons to be loaded into Piwi/Aubergine/AGO3 and a subset of piRNAs un...

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Hlavní autoři: Olivieri, Daniel, Sykora, Martina M, Sachidanandam, Ravi, Mechtler, Karl, Brennecke, Julius
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957214/
https://ncbi.nlm.nih.gov/pubmed/20818334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.212
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