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Metal binding and substrate positioning by evolutionarily invariant U6 sequences in catalytically active protein-free snRNAs

We have previously shown that a base-paired complex formed by two of the spliceosomal RNA components, U6 and U2 small nuclear RNAs (snRNAs), can catalyze a two-step splicing reaction that depended on an evolutionarily invariant region in U6, the ACAGAGA box. Here we further analyze this RNA-catalyze...

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Main Authors: Lee, Caroline, Jaladat, Yasaman, Mohammadi, Afshin, Sharifi, Armin, Geisler, Sarah, Valadkhan, Saba
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957061/
https://ncbi.nlm.nih.gov/pubmed/20826700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2170910
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