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Metal binding and substrate positioning by evolutionarily invariant U6 sequences in catalytically active protein-free snRNAs
We have previously shown that a base-paired complex formed by two of the spliceosomal RNA components, U6 and U2 small nuclear RNAs (snRNAs), can catalyze a two-step splicing reaction that depended on an evolutionarily invariant region in U6, the ACAGAGA box. Here we further analyze this RNA-catalyze...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2957061/ https://ncbi.nlm.nih.gov/pubmed/20826700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2170910 |
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