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Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing

Splicing of introns from mRNA precursors is a two-step reaction performed by the spliceosome, an immense cellular machine consisting of over 200 different proteins and five small RNAs (snRNAs). We previously demonstrated that fragments of two of these RNAs, U6 and U2, can catalyze by themselves a sp...

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Bibliografiset tiedot
Päätekijät: Valadkhan, Saba, Mohammadi, Afshin, Wachtel, Chaim, Manley, James L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2007
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2080592/
https://ncbi.nlm.nih.gov/pubmed/17940139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.626207
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