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Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.

We previously identified a Plasmodium falciparum trophozoite cysteine proteinase (TCP) and hypothesized that it is required for the degradation of host hemoglobin by intraerythrocytic malaria parasites. To test this hypothesis and to evaluate TCP as a chemotherapeutic target, we examined the antimal...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Rosenthal, P J, Wollish, W S, Palmer, J T, Rasnick, D
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1991
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295650/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1939639/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115456
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