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Hsp70 and Hsp90 mediated proteasomal degradation underlies TPI(sugarkill) pathogenesis in Drosophila
Triosephosphate isomerase (TPI) deficiency is a severe glycolytic enzymopathy that causes progressive locomotor impairment and neurodegeneration, susceptibility to infection, and premature death. The recessive missense TPI(sugarkill) mutation in Drosophila melanogaster exhibits phenotypes analogous...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955819/ https://ncbi.nlm.nih.gov/pubmed/20727972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.08.011 |
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