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Hsp70 and Hsp90 mediated proteasomal degradation underlies TPI(sugarkill) pathogenesis in Drosophila

Triosephosphate isomerase (TPI) deficiency is a severe glycolytic enzymopathy that causes progressive locomotor impairment and neurodegeneration, susceptibility to infection, and premature death. The recessive missense TPI(sugarkill) mutation in Drosophila melanogaster exhibits phenotypes analogous...

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Bibliografski detalji
Glavni autori: Hrizo, Stacy L., Palladino, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955819/
https://ncbi.nlm.nih.gov/pubmed/20727972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.08.011
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