Computational analysis and modeling of cleavage by the immunoproteasome and the constitutive proteasome

BACKGROUND: Proteasomes play a central role in the major histocompatibility class I (MHCI) antigen processing pathway. They conduct the proteolytic degradation of proteins in the cytosol, generating the C-terminus of CD8 T cell epitopes and MHCI-peptide ligands (P1 residue of cleavage site). There a...

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Main Authors: Diez-Rivero, Carmen M, Lafuente, Esther M, Reche, Pedro A
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955702/
https://ncbi.nlm.nih.gov/pubmed/20863374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-11-479
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