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Control of established melanoma by CD27 stimulation is associated with enhanced effector function and persistence, and reduced PD-1 expression, of tumor infiltrating CD8(+) T cells
The immune response to tumor can be enhanced by targeting costimulatory molecules on T cells. As the CD70-CD27 costimulatory axis plays an important role in the activation, survival and differentiation of lymphocytes, we have examined the efficacy of agonistic anti-CD27 antibodies as monotherapies f...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955154/ https://ncbi.nlm.nih.gov/pubmed/20842060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181ee238f |
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