Impaired enolase 1 glycolytic activity restrains effector functions of tumor infiltrating CD8+ T cells

In the context of solid tumors, there is a positive correlation between the accumulation of cytotoxic CD8+ tumor infiltrating lymphocytes (TILs) and favorable clinical outcomes. However, CD8+ TILs often exhibit a state of functional exhaustion limiting their activity, and the underlying molecular ba...

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Pubblicato in:Sci Immunol
Autori principali: Gemta, Lelisa F., Siska, Peter J., Nelson, Marin E., Gao, Xia, Liu, Xiaojing, Locasale, Jason W., Yagita, Hideo, Slingluff, Craig L., Hoehn, Kyle L., Rathmell, Jeffrey C., Bullock, Timothy N.J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824424/
https://ncbi.nlm.nih.gov/pubmed/30683669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aap9520
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