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Impaired enolase 1 glycolytic activity restrains effector functions of tumor infiltrating CD8+ T cells
In the context of solid tumors, there is a positive correlation between the accumulation of cytotoxic CD8+ tumor infiltrating lymphocytes (TILs) and favorable clinical outcomes. However, CD8+ TILs often exhibit a state of functional exhaustion limiting their activity, and the underlying molecular ba...
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| 出版年: | Sci Immunol |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6824424/ https://ncbi.nlm.nih.gov/pubmed/30683669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aap9520 |
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