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Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease
Stargardt disease (STGD) is the major form of inherited juvenile macular degeneration. Pyridinium bis-retinoid A2E is a major component of lipofuscin which accumulates in retinal pigment epithelium (RPE) cells in STGD and contributes to the disease pathogenesis. However, the precise role of A2E in v...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2955102/ https://ncbi.nlm.nih.gov/pubmed/20876139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008769107 |
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