Pharmacological chaperone for the structured domain of human prion protein

In prion diseases, the misfolded protein aggregates are derived from cellular prion protein (PrP(C)). Numerous ligands have been reported to bind to human PrP(C) (huPrP), but none to the structured region with the affinity required for a pharmacological chaperone. Using equilibrium dialysis, we scre...

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Detalles Bibliográficos
Autores principales: Nicoll, Andrew J., Trevitt, Clare R., Tattum, M. Howard, Risse, Emmanuel, Quarterman, Emma, Ibarra, Amaurys Avila, Wright, Connor, Jackson, Graham S., Sessions, Richard B., Farrow, Mark, Waltho, Jonathan P., Clarke, Anthony R., Collinge, John
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955083/
https://ncbi.nlm.nih.gov/pubmed/20876144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009062107
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