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Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis
Here, we show that CDK2, an S-phase cyclin-dependent kinase, is a novel target for Akt during cell cycle progression and apoptosis. Akt phosphorylates CDK2 at threonine 39 residue both in vitro and in vivo. Although CDK2 threonine 39 phosphorylation mediated by Akt enhances cyclin-A binding, it is d...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2954964/ https://ncbi.nlm.nih.gov/pubmed/18354084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.009530 |
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