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Switching Akt: from survival signaling to deadly response

Akt, a protein kinase hyperactivated in many tumors, plays a major role in both cell survival and resistance to tumor therapy. A recent study,(1) along with other evidences, shows interestingly, that Akt is not a single-function kinase, but may facilitate rather than inhibit cell death under certain...

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Hlavní autoři: Los, Marek, Maddika, Subbareddy, Erb, Bettina, Schulze-Osthoff, Klaus
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954189/
https://ncbi.nlm.nih.gov/pubmed/19319914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.200900005
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