ATM-Dependent Phosphorylation of ATF2 Is Required for the DNA Damage Response

Activating transcription factor 2 (ATF2) is regulated by JNK/p38 in response to stress. Here, we demonstrate that the protein kinase ATM phosphorylates ATF2 on serines 490 and 498 following ionizing radiation (IR). Phosphoantibodies to ATF2(490/8) reveal dose- and time-dependent phosphorylation of A...

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Hlavní autoři: Bhoumik, Anindita, Takahashi, Shoichi, Breitweiser, Wolfgang, Shiloh, Yosef, Jones, Nic, Ronai, Ze'ev
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954254/
https://ncbi.nlm.nih.gov/pubmed/15916964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2005.04.015
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