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Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity

The notorious resistance of melanoma cells to drug treatment can be overcome by expression of a 50-aa peptide derived from activating transcription factor 2 (ATF2(50–100)). Here we demonstrate that ATF2(50–100) induced apoptosis by sequestering ATF2 to the cytoplasm, thereby inhibiting its transcrip...

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Detalhes bibliográficos
Main Authors: Bhoumik, Anindita, Jones, Nic, Ronai, Ze'ev
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC384722/
https://ncbi.nlm.nih.gov/pubmed/15010535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400195101
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