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Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity
The notorious resistance of melanoma cells to drug treatment can be overcome by expression of a 50-aa peptide derived from activating transcription factor 2 (ATF2(50–100)). Here we demonstrate that ATF2(50–100) induced apoptosis by sequestering ATF2 to the cytoplasm, thereby inhibiting its transcrip...
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| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2004
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC384722/ https://ncbi.nlm.nih.gov/pubmed/15010535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400195101 |
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