Identification of β-catenin as a target of the intracellular tyrosine kinase PTK6

Disruption of the gene encoding protein tyrosine kinase 6 (PTK6) leads to increased growth, impaired enterocyte differentiation and higher levels of nuclear β-catenin in the mouse small intestine. Here, we demonstrate that PTK6 associates with nuclear and cytoplasmic β-catenin and inhibits β-catenin...

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Bibliographic Details
Main Authors: Palka-Hamblin, Helena L., Gierut, Jessica J., Bie, Wenjun, Brauer, Patrick M., Zheng, Yu, Asara, John M., Tyner, Angela L.
Format: Artigo
Language:Inglês
Published: Company of Biologists 2010
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954247/
https://ncbi.nlm.nih.gov/pubmed/20026641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.053264
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