Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates

PURPOSE: ABT-888 inhibits poly(ADP-ribose) polymerase (PARP) and may enhance the efficacy of chemotherapy and radiation in CNS tumors. We studied the plasma and cerebrospinal fluid (CSF) pharmacokinetics (PK) of ABT-888 in a non-human primate (NHP) model that is highly predictive of human CSF penetr...

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Bibliografiska uppgifter
Huvudupphovsmän: Muscal, Jodi A., Thompson, Patrick A., Giranda, Vincent L., Dayton, Brian D., Bauch, Joy, Horton, Terzah, McGuffey, Leticia, Nuchtern, Jed G., Dauser, Robert C., Gibson, Brian W., Blaney, Susan M., Su, Jack M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953793/
https://ncbi.nlm.nih.gov/pubmed/19526240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1044-3
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