Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates

PURPOSE: ABT-888 inhibits poly(ADP-ribose) polymerase (PARP) and may enhance the efficacy of chemotherapy and radiation in CNS tumors. We studied the plasma and cerebrospinal fluid (CSF) pharmacokinetics (PK) of ABT-888 in a non-human primate (NHP) model that is highly predictive of human CSF penetr...

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Detalhes bibliográficos
Main Authors: Muscal, Jodi A., Thompson, Patrick A., Giranda, Vincent L., Dayton, Brian D., Bauch, Joy, Horton, Terzah, McGuffey, Leticia, Nuchtern, Jed G., Dauser, Robert C., Gibson, Brian W., Blaney, Susan M., Su, Jack M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953793/
https://ncbi.nlm.nih.gov/pubmed/19526240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1044-3
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