Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates

PURPOSE: ABT-888 inhibits poly(ADP-ribose) polymerase (PARP) and may enhance the efficacy of chemotherapy and radiation in CNS tumors. We studied the plasma and cerebrospinal fluid (CSF) pharmacokinetics (PK) of ABT-888 in a non-human primate (NHP) model that is highly predictive of human CSF penetr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Muscal, Jodi A., Thompson, Patrick A., Giranda, Vincent L., Dayton, Brian D., Bauch, Joy, Horton, Terzah, McGuffey, Leticia, Nuchtern, Jed G., Dauser, Robert C., Gibson, Brian W., Blaney, Susan M., Su, Jack M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953793/
https://ncbi.nlm.nih.gov/pubmed/19526240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1044-3
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg