Influence of Reduced Folate Carrier and Dihydrofolate Reductase Genes on Methotrexate-Induced Cytotoxicity

PURPOSE: The aim of this study is to investigate the effect of genetic variations and the expression of the reduced folate carrier (RFC) and dihydrofolate reductase (DHFR) on the drug sensitivity to methotrexate (MTX) in different cancer cell lines. MATERIALS AND METHODS: We examined the six human c...

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Bibliografiske detaljer
Main Authors: Yoon, Seong-Ae, Choi, Jung Ran, Kim, Jeong-Oh, Shin, Jung-Young, Zhang, XiangHua, Kang, Jin-Hyoung
Format: Artigo
Sprog:Inglês
Udgivet: Korean Cancer Association 2010
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953780/
https://ncbi.nlm.nih.gov/pubmed/20948922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2010.42.3.163
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