Influence of Reduced Folate Carrier and Dihydrofolate Reductase Genes on Methotrexate-Induced Cytotoxicity

PURPOSE: The aim of this study is to investigate the effect of genetic variations and the expression of the reduced folate carrier (RFC) and dihydrofolate reductase (DHFR) on the drug sensitivity to methotrexate (MTX) in different cancer cell lines. MATERIALS AND METHODS: We examined the six human c...

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Bibliographic Details
Main Authors: Yoon, Seong-Ae, Choi, Jung Ran, Kim, Jeong-Oh, Shin, Jung-Young, Zhang, XiangHua, Kang, Jin-Hyoung
Format: Artigo
Language:Inglês
Published: Korean Cancer Association 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953780/
https://ncbi.nlm.nih.gov/pubmed/20948922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2010.42.3.163
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