Influence of Reduced Folate Carrier and Dihydrofolate Reductase Genes on Methotrexate-Induced Cytotoxicity

PURPOSE: The aim of this study is to investigate the effect of genetic variations and the expression of the reduced folate carrier (RFC) and dihydrofolate reductase (DHFR) on the drug sensitivity to methotrexate (MTX) in different cancer cell lines. MATERIALS AND METHODS: We examined the six human c...

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Autores principales: Yoon, Seong-Ae, Choi, Jung Ran, Kim, Jeong-Oh, Shin, Jung-Young, Zhang, XiangHua, Kang, Jin-Hyoung
Formato: Artigo
Lenguaje:Inglês
Publicado: Korean Cancer Association 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953780/
https://ncbi.nlm.nih.gov/pubmed/20948922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2010.42.3.163
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