Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

BACKGROUND: Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analogous mutations can be...

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Main Authors: Choowongkomon, Kiattawee, Theppabutr, Sasikrit, Songtawee, Napat, Day, Nicholas PJ, White, Nicholas J, Woodrow, Charles J, Imwong, Mallika
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838911/
https://ncbi.nlm.nih.gov/pubmed/20193090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-9-65
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