Regulation of Eukaryotic Initiation Factor 4E (eIF4E) Phosphorylation by Mitogen-Activated Protein Kinase Occurs through Modulation of Mnk1-eIF4G Interaction

The m(7)G cap binding protein eukaryotic initiation factor 4E (eIF4E) is a rate-limiting determinant of protein synthesis. Elevated eIF4E levels, commonly associated with neoplasia, promote oncogenesis, and phosphorylation of eIF4E at Ser209 is critical for its tumorigenic potential. eIF4E phosphory...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Shveygert, Mayya, Kaiser, Constanze, Bradrick, Shelton S., Gromeier, Matthias
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953056/
https://ncbi.nlm.nih.gov/pubmed/20823271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00448-10
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares