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Poly(A)-binding protein is differentially required for translation mediated by viral internal ribosome entry sites
The 3′ poly(A) tail present on the majority of mature eukaryotic mRNAs is an important regulator of protein synthesis and mRNA stability. The poly(A) tail improves the efficiency of translation initiation through recruitment of PABP, enabling its interaction with eIF4F located at the mRNA 5′-end. Re...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Cold Spring Harbor Laboratory Press
2007
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1950770/ https://ncbi.nlm.nih.gov/pubmed/17652408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.556107 |
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