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Mitotic Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1232 by Cdk1:Cyclin B Inhibits eIF4A Helicase Complex Binding with RNA

During mitosis, global translation is suppressed, while synthesis of proteins with vital mitotic roles must go on. Prior evidence suggests that the mitotic translation shift involves control of initiation. Yet, no signals specifically targeting translation initiation factors during mitosis have been...

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Hlavní autoři: Dobrikov, Mikhail I., Shveygert, Mayya, Brown, Michael C., Gromeier, Matthias
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911517/
https://ncbi.nlm.nih.gov/pubmed/24248602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01046-13
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