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Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma.

The expression of the insulin-like growth factors (IGFs) and their receptors has been linked to cellular proliferation and tumorigenicity in a number of model systems. Since rhabdomyosarcoma cells express IGF-I receptors, an autocrine or paracrine loop involving this receptor and its ligands could b...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Shapiro, D N, Jones, B G, Shapiro, L H, Dias, P, Houghton, P J
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1994
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295208/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8083365/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117441
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