Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1

Interleukin 15 (IL-15) promotes the survival of natural killer (NK) cells by preventing apoptosis through mechanisms unknown at present. Here we identify Bim, Noxa and Mcl-1 as key regulators of IL-15-dependent survival of NK cells. IL-15 suppressed apoptosis by limiting Bim expression through the k...

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Detalhes bibliográficos
Main Authors: Huntington, Nicholas D, Puthalakath, Hamsa, Gunn, Priscilla, Naik, Edwina, Michalak, Ewa M, Smyth, Mark J, Tabarias, Hyacinth, Degli-Esposti, Mariapia A, Dewson, Grant, Willis, Simon N, Motoyama, Noboru, Huang, David C S, Nutt, Stephen L, Tarlinton, David M, Strasser, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951739/
https://ncbi.nlm.nih.gov/pubmed/17618288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1487
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