Intracellular Trafficking and Decondensation Kinetics of Chitosan–pDNA Polyplexes

The transfection efficiency (TE) of chitosan–plasmid DNA (pDNA) polyplexes can be critically modulated by the polymer degree of deacetylation (DDA) and molecular weight (MW). This study was performed to test the hypothesis that the TE dependence on chitosan MW and DDA is related to the polyplex stab...

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Main Authors: Thibault, Marc, Nimesh, Surendra, Lavertu, Marc, Buschmann, Michael D
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951560/
https://ncbi.nlm.nih.gov/pubmed/20628361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.143
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