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Defining the mechanism of polymerization in the serpinopathies
The serpinopathies result from the ordered polymerization of mutants of members of the serine proteinase inhibitor (serpin) superfamily. These polymers are retained within the cell of synthesis where they cause a toxic gain of function. The serpinopathies are exemplified by inclusions that form with...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951428/ https://ncbi.nlm.nih.gov/pubmed/20855577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004785107 |
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