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Molecular basis of von Willebrand disease type IIB. Candidate mutations cluster in one disulfide loop between proposed platelet glycoprotein Ib binding sequences.

Many variants of von Willebrand disease (vWD) with qualitatively abnormal von Willebrand factor (vWF) are recognized. In vWD type IIB, the abnormal protein displays enhanced affinity for a platelet vWF receptor, the glycoprotein Ib-IX complex. 14 patients from 7 unrelated families with vWD type IIB...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Randi, A M, Rabinowitz, I, Mancuso, D J, Mannucci, P M, Sadler, J E
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1991
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC295140/
https://ncbi.nlm.nih.gov/pubmed/2010538
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