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Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme

How living systems detect the presence of genotoxic damage embedded in a million-fold excess of undamaged DNA is an unresolved question in biology. Here we have captured and structurally elucidated a base-excision DNA repair enzyme, MutM, at the stage of initial encounter with a damaged nucleobase,...

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Main Authors: Qi, Yan, Spong, Marie C., Nam, Kwangho, Banerjee, Anirban, Jiralerspong, Sao, Karplus, Martin, Verdine, Gregory L.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951314/
https://ncbi.nlm.nih.gov/pubmed/20010681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08561
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